認知症　DEMENTIA
西崎創薬研究所

認知機能改善　ウリジン

ウリジン
認知機能を改善する！

  • PKCεは、認知機能を高める重要なタンパク質リン酸化酵素です。

    RNAの構成成分のひとつであるウリジンは、ATPの加水分解を促進することによってPKCεの活性化を増強します。

    ウリジンと同様の作用が、向知性薬ネフィラセタムでも認められます。

    ウリジンは、アラキドン酸やリノール酸などの不飽和脂肪酸によるPKCε活性化を増強し、シナプス前終末細胞膜上のα7アセチルコリン受容体の数を増加させます。

    その結果、グルタミン酸放出が刺激され、シナプス活動が活発（＝認知機能促進）になります。

    このように、食物に含まれるウリジンは認知機能を改善する作用があります。

ウリジン
文献
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